![]() ![]() “There are enough projects worldwide for solar that it is real, and that the economics do work now. Lester says the city is embracing being the first in the state to power its government through solar energy, but that it likely won’t be the last. Halter says the two Clarksville plants are expected to reduce carbon emissions by over 300,000 metric tons over 30 years. And they'll be doing that for the next 35 years, so it's a real significant economic development benefit for Clarksville as well,” Halter said. “These two power plants together are producing over 15 million kilowatt hours a year of electricity, and the market value of that is more than $1.5 million a year. Halter says cost savings, coupled with the public boost Clarksville gets from its first-in-the-state status will offer $5 million in economic development opportunities to the small community of about 9,000. KUAR News Clarksville city officials and residents pose for a ribbon cutting ceremony at the city's new 2 megawatt solar power plant. “Having that technology and then having a renewable portfolio is becoming more and more of interest when it comes to sustainability in corporate America, so we're hoping that it gets us on the radar for future jobs.” So we're adding that utility to our existing utilities which is electric, water and wastewater,” Lester said. “We've got about 4,500 households, business customers, and we're doing that fiber to the home project where we can deliver a gig worth of internet to anybody at any location for about $90 a month. Lester says the energy savings have freed up the city budget to address other infrastructure projects, like offering fiber optic high-speed internet service to the community nestled in the Ozark foothills. “They're going to save money, they're going to lock in a lower price of electricity for the next 35 years.” “This is a community that embraced the future and said, ‘We understand we’re taking a little bit of a risk here, we’re doing things unconventionally, but it's the right thing to do and it's paid off,’” Halter said. Bill Halter says the city has embraced the project despite the up-front costs. Scenic Hill Solar CEO and former Arkansas Lt. The two plants combined produce enough energy to power all city government buildings. The first 5 megawatt plant opened in 2018, and was an investment of roughly $10 million about what the city would have spent for eight months’ worth of power from outside utility companies. ![]() “They allowed us to build up to 7.3 megawatts of solar capacity as part of that agreement so we started looking at the economics of it, the economics worked, so we decided to do the first power plant and at that time it was the largest municipal power plant in the state of Arkansas,” Lester said. John Lester, general manager of Clarksville Connected Utilities, says the idea to use solar power came from a contract the city had with an Oklahoma-based power company. This marks the city’s second solar power plant built through a partnership between the city-owned utility company and North Little Rock-based Scenic Hill Solar. The opening of a new 2 megawatt solar power plant on Wednesday makes the city of Clarksville in western Arkansas the first in the state to power all of its governmental operations with solar energy. ![]()
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![]() Drywall fiberglass mesh tape can be easily applied with a trowel or roller, making it ideal for large drywall repair jobs. The two materials have distinct finish qualities, providing different performance levels in finished walls. Topics of Discussion: Is it possible to install stacked stone on painted drywall 04. It takes much longer to do correctly and, as such, puts an additional strain on a DIYer’s timeline for getting the job done. In contrast, paper tape requires that you first spread drywall mud over the wall before you semi-bury the paper tape to reinforce the seams. Drywall mesh is typically easier and quicker to install than paper tape it already comes with adhesive on the back, so you can easily attach it to the surface without applying any extra adhesive or mud. They both serve the same purpose of reinforcing the seams and corners of a drywall panel but differ in installation time. This allows them to conform much better with complex shapes and surfaces than mesh tapes can while providing better overall coverage. The open weave design gives the tape more room to expand and contract with the surface, a must for large-format walls that may shift due to natural expansion or contraction through changing temperatures and humidity levels.īut, when talking about adhesion strength alone, paper tapes tend to be superior because they fill gaps more effectively than mesh due to their flexibility. ![]() ![]() Generally speaking, mesh tapes have a stronger adhesion capability (because of their self-adhesive formula) than standard paper tapes, making them better for use in higher-stress applications such as corners and high-traffic areas. This makes paper tape easier to work with around curves and corners. Paper drywall tape is best used inside corner joints as it lies flat against the surface without scaling. On the other hand, paper tape requires the edges of a freshly applied layer of joint compound to be feathered for proper adhesion before sticking onto wall surfaces. It’s also reinforced, making it ideal for larger surface areas and more load-bearing spaces, such as walls that need to hold a heavy coat of paint or texture. Mesh tape is made of self-adhesive fiberglass and offers excellent reinforcement, while the paper tape is more flexible and easier to apply.ĭrywall mesh wall tape is best used to hide blemishes or tricky corners that can’t be covered with paper tape. The following are the main differences between drywall mesh tape and paper adhesive tape: 01. While paper and mesh tape are popular for finishing and concealing joints between drywall panels, each option has different characteristics. When it comes to drywall taping, most professionals have their preferences. Drywall Mesh Tape vs Paper Tape: What are the Differences? By reading on, you will discover the differences between drywall mesh and paper tape and which is the best option for you. Though these two types of tape are meant for the same purpose, there are a few key differences between them. But which drywall tape should you use, drywall mesh tape or paper adhesive tape? Besides creating a tight bond between drywall panels, taping also fills in any irregularities or gaps, resulting in an even surface. Taping drywall provides an extra layer of protection against moisture and humidity, preventing future cracks and disintegration of the drywall’s surface. Choose the appropriate non-shrink drywall joint tape to ensure a flawless finish. If these seams are not reinforced with tape, cracks and bulges may develop over time, making repairs nearly improbable. 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![]() ![]() ![]() Sauce (water, Pasteurized Process White Cheddar Cheese, Soybean Oil, Whey Protein Concentrate, Cayenne Pepper Puree, Nonfat Milk, Distilled White Vinegar, Modified Cornstarch, Sodium Phosphate, Modified Cellulose, Potassium Chloride, Annato Extract ), Cooked Enriched Macaroni Product (water, Enriched Macaroni Product, Carrageenan), Fully Cooked Boneless Breaded Chicken Breast Meat With Rib Meat (chicken Breast Meat With Rib Meat, Water, Salt, Potato Starch, Sodium Phosphates. Convenient frozen dinner stores easily in your freezer until you’re ready to enjoy.Microwave this dish in 6 minutes for fast preparation.Includes a microwaveable serving tray for fast cooking.Contains pasta shells with buffalo style cheddar sauce, crispy breaded frozen chicken and rich blue cheese.Buffalo style cheddar cheese sauce delivers creamy, gooey goodness with the perfect amount of heat.DEVOUR Buffalo Style Chicken Mac & Cheese frozen dinners are made with quality chicken breast.One 12 oz box of DEVOUR Buffalo Style Chicken Mac & Cheese Frozen Meal.Show your mouth a good time and enjoy a mouthwatering, decadent macaroni & cheese meal with a twist. DEVOUR frozen meals make it easy to enjoy hot, mouth-watering food at home or in the break room, so be sure to keep your freezer stocked with our delicious frozen food. Ready to eat in minutes, each 12 ounce frozen buffalo style chicken macaroni tv dinner comes with a microwaveable serving tray for fast and convenient feasting. Finally, we topped it all with rich blue cheese to cool you down just right. We combined perfectly cooked pasta shells with crispy breaded chicken and then drenched it in creamy buffalo style cheddar sauce. Our hearty macaroni and cheese microwave meal is sure to satisfy big appetites. ![]() Now this post is really making me want this meal and I have a package sitting in my freezer….DEVOUR Buffalo Style Chicken Mac & Cheese Frozen MealĭEVOUR Buffalo Style Chicken Mac & Cheese dials up the taste, maxes out the flavor and turns up the texture with an easy-to-make single-serve frozen dinner. I like having a salad on the side of this for more veggies, and it is also good with Joseph’s Mini Pitas warmed up and then you can dip it in the extra cheese sauce :). or really any protein you want or none at all!Īfter I add the cheeses and protein I microwave it all for a little bit longer and stir it, then I add hot sauce, depending on the day I will add a lot or a little… up to you:) I add the ground turkey for more protein, but you can also add chicken. I love adding the cream cheese and extra cheese because you can never have enough cheese in my opinion, and if you want to give it more of a buffalo mac feel the cream cheese really helps. that being said I just log half of entire package. I always split the package because the nutrition states that 111 grams frozen is the serving size but I am not going to open the package and weigh it because then the bag would no longer be able to steam it. It is super macro friendly because the pasta is made out of zucchini and lentils and when I saw it in the frozen section I knew I had to try it! I have tried a lot of the Birdseye pastas, and they are ALL good but this one is hands down my favorite!Īll you have to do is microwave the bag and it steams the pasta making it cheesy and good. This recipe goes way back for me, this was one of the first recipes I religiously followed when I first started macro tracking because it is just simply amazing and cheesy, but it is also so easy! Low calorie, buffalo mac and cheese, the is so easy to make, so cheesy, and delicious! This recipe uses frozen veggie pasta, so all you are going to need is a microwave and an appetite! ![]() ![]() We also searched for sweep signatures in Drosophila melanogaster, finding expected candidates at Ace, Uhg1, and Pimet. Accordingly, we applied the T statistic to variant calls from European and sub-Saharan African human populations, yielding primarily literature-supported candidates, including LCT, RSPH3, and ZNF211 in CEU, SYT1, RGS18, and NNT in YRI, and HLA genes in both populations. We found that the T statistic is suitable for detecting both hard and soft sweeps across a variety of demographic models, selection strengths, and ages of the beneficial allele. Our framework uses a simple but powerful model of haplotype frequency spectrum distortion to find sweeps and additionally make an inference on the number of presently sweeping haplotypes in a population. Here, we propose a likelihood ratio test statistic T to probe whole-genome polymorphism data sets for selective sweep signatures. Multiple methods exist to locate selective sweeps in the genome from haplotype data, but none leverages the power of a model-based approach to make their inference. Following a selective sweep, haplotypic diversity surrounding the site under selection decreases, and this deviation from the background pattern of variation can be applied to identify sweeps. Selective sweeps are frequent and varied signatures in the genomes of natural populations, and detecting them is consequently important in understanding mechanisms of adaptation by natural selection. ![]() ![]() ![]() This cookie is set by GDPR Cookie Consent plugin. The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional". The cookie is used to store the user consent for the cookies in the category "Analytics". ![]() Set by the GDPR Cookie Consent plugin, this cookie is used to record the user consent for the cookies in the "Advertisement" category. These cookies ensure basic functionalities and security features of the website, anonymously. To set a max displayed value higher than 255 in QuPath for RGB images, you just need to double click on the upper bound of the B&C window.Necessary cookies are absolutely essential for the website to function properly. displayed img1+img2 → 180 (which is If you set a max displayed value higher than 255, for instance with a max at 512 instead of 256, you get: In QuPath as in BigDataViewer, there is a scaling that you can apply from the data RGB value to the rendered RGB value, allowing to avoid saturation when blending with sum: For brightfield images, blending a pixel of intensity 170 (img1) with another of intensity 190 (img2) will get you a white saturated displayed pixel (170+190 > 255). If I understand correctly, the problem is the rendering/blending of 2 rgb images. But I don’t really get why BDV is giving a better color rendering that QuPath, since QuPath has more built-in options, like color deconvolution. It’s doable to some extent to export the view from BigDataViewer, it’s clunky but it works (I can make a small gif if you think that’s useful). ![]() Top-left: single-stain #1 (i.e., moving image), top-right: color converted single-stain #1 (note: just for visualization purposes), bottom-left: single-stain #2 (i.e., target image), bottom-right: overlay of alignment of single-stain #1 and single-stain #2 I’ve also tried exporting images in ome.tiff format to be color corrected elsewhere (e.g., a Python environment) but creation of these images has been computationally expensive given the image size. I’ve tried other color combinations but these settings seem to be the best thus far. I selected these image types so that I can express the overlay using eosin and DAB channels, respectively, and to visually differentiate the individual stained sections (bit of a cheat). Technical specification of output images: Image type: Single-stain #1 (i.e., moving) = H&E-other, Single-stain #2 (i.e., target) = H&E-DAB Technical specifications of input images:įile type =. Downstream analyses will involve manual region/patch- and cellular-level annotations so an optimal visualization of the alignment overlay is important. Coercing the background color to white or off-white would be ideal. More specifically, the color selection should provide a greater contrast between the overlay and the background. My group is very satisfied with the alignment quality but I’ve been asked to improve the visualization itself. In the example below, I show two sample single-stain IHC images and the resulting alignment overlay. I’ve loaded multiple series of single-stain IHC images into QuPath and then aligned them using the Warpy plug-in in ImageJ/Fiji. ![]() ![]() ![]() Sudoku is played on 9 x 9 grid, divided into 3 x 3 squares separated from each other by thicker lines. Later, newspapers all over the world started including these games in their publications. Nikoli’s sudoku version later spread throughout the world thanks to Wayne Gould, a retired Hong Kong judge who first encounter the game in a Tokyo bookstore and later published a book with his own puzzles in the UK and the US. As the game’s popularity increased in Japan, its designation was eventually shortened to include only the characters for number (数 - Su) and single (独 - Doku), resulting in the name by which we now know it, Sudoku. The second and most import rule is that no more than 32 numbers out of the 81 can be given away, as the goal becomes too easy to reach above this threshold. The given numbers in the beginning must create a pattern in their allocated squares to make the game more visually appealing to the players. Nikoli also introduced two new rules that became essential to the game as we know it today. ![]() Its widespread popularity didn’t come until the game reached Japan in 1984 when Nikoli published it under the name “Suuji wa dokushin ni kaguru” (The numbers must remain single) in the Monthly Nikolist Magazine. The modern Sudoku as we know it nowadays, however, using digits instead of the Latin alphabet, was most likely the creation of Howard Garns, an architect from Indiana who first published his version of the game in the Dell Magazines in 1979. ![]() The basis of the game originated in Switzerland in the 18th century when the mathematician Leonhard Euler developed the concept of Latin Squares used in statistical analysis. Sudoku is a number-placement puzzle widely popular in the world, credited with helping to keep the brain active and healthy. Let the cogs on your brain spin and enjoy this relaxing yet challenging puzzle. Don’t rush, analyzed all your possibilities and slowly work your way to fill the grid. Time is not a constraint and only logic is necessary. Experts and pros can also have their fun and enjoy playing with the numbers and possibilities with the hard and evil levels. If you feel confident in your skills from the beginning, you can put them to test with the medium level and face demanding challenges right from the start. The harder the level, the fewer allocated numbers at the beginning of the puzzle.īeginners can start by choosing the easy level to get acquainted with the digits, the grid and the rules of the puzzle. Start by choosing any of the four different levels of difficulty: Get set, relax and prepare to challenge your brain with this number-placement puzzle anywhere and anytime. ![]() ![]() In another study, T cell clones present in both tumors and peripheral blood were investigated to analyze their ongoing immune responses. In addition, the same CD8-positive T cell clones were enriched in the peripheral blood and tumors after treatment with an anti-CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) antibody. In melanoma patients, the repertoire of CD8-positive T cells in the peripheral blood was more restricted than that of CD4-positive T cells. The TCR repertoire of CD8-positive T cells in the blood of melanoma patients was significantly more restricted than that in healthy individuals. įurthermore, the TCR repertoire in melanoma patients before starting immunotherapy was compared with that in healthy individuals. Treatment with these proliferated lymphocytes administered concomitantly with an anti-PD-1 antibody led to successful outcomes in melanoma patients. Furthermore, the TCR repertoire of peripheral blood PD-1-positive lymphocytes proliferated in vitro is highly similar to that of TILs. A recent study showed a relatively large overlap between the TCR repertoire of TILs and that of CD8-positive PD-1 (programmed cell death 1)-positive T cells in the peripheral blood. Tumor-infiltrating lymphocytes (TILs) form a polyclonal population in which T cells targeting known and unknown tumor-specific antigens, such as tumor-associated antigens and neoantigens, are enriched. Therefore, the tumor-infiltrating CD8-positive T cell count is a prognostic factor in patients with cancer. The therapeutic efficacy of ICIs and changes in the repertoire are described in detail later.ĬD8-positive T cells recognize tumor antigens via MHC class I and play a major role in tumor immunity. The therapeutic efficacy of ICIs is correlated with the proliferation of T cell clones possessing TCRs that recognize tumor antigens (decrease in the T cell repertoire size). The sequencing efforts have been focused particularly on CD8-positive T cells, which play a central role in immune responses to tumors. In particular, complementarity determining region 3 (CDR3) of the TCR is highly diversified and has sequences that are unique to individual T cell clones, and T cell responses can be traced by sequencing the CDR3 regions of TCRs. The large variety of TCRs required for effective immune function is produced via error-prone recombination of the TCR loci. Tumor-specific T cells develop as a response to tumor antigens, including individual “neoantigens” derived from mutant proteins of cancer cells. The recognition of an antigen by a TCR results in the activation and proliferation of antigen-reactive T cells, and a process of clonal proliferation is triggered. Through unique TCRs on individual T cells, T cells can scan antigens presented by MHC molecules on the surface of tumor cells. Once the TCR binds to a peptide, signal transduction occurs, which promotes activation, proliferation, differentiation, cytokine production, and an increase in cytolytic activity. TCRs are responsible for the sensitivity and specificity of T cells to peptides presented by MHC. Such a large number of unique clonotypes are stochastically generated via V(D)J recombination in thymic T cell progenitors, followed by positive and negative selection, which select T cells that bind to major histocompatibility complex (MHC) but not to self-peptides. There are between 2 × 10 9 and 6 × 10 9 unique TCRs in the circulating T cell population of a healthy individual. T cells expressing αβTCR are referred to as αβT cells, whereas T cells expressing γδTCR are referred to as γδT cells. ![]() Most T cells express αβTCR, a heterodimer of TCRα and TCRβ chains, whereas some T cells express γδTCR, a heterodimer of TCRγ and TCRδ chains. T cells are activated by the recognition of corresponding antigens via TCRs. Further analyses of the repertoire of immune cells are desirable to improve and predict the therapeutic efficacy of ICIs. Moreover, changes in the repertoire at an early stage of treatment seem to be useful for predicting the therapeutic efficacy of ICIs. ![]() Clonal proliferation has been detected not only in CD8-positive T cells but also in CD4-positive T cells, resident memory T cells, and B cells. The proliferation of these T cell clones is observed within tumors as well as in the peripheral blood. The proliferation of T cell clones against tumor antigens is detected in patients who respond to treatment with ICIs. Since tumor immune responses are based on antigen-specific immune responses, investigators have focused on T cell receptors (TCRs) and have analyzed changes in the TCR repertoire. Mechanistic exploration of tumor immune responses is essential to improve the therapeutic efficacy of ICIs. Immune checkpoint inhibitors (ICIs) have been used for the treatment of various types of cancers, including malignant melanoma. ![]() ![]() There's lots to think about before you write your book. Need some help? Plan your book with The Novel-Writing Training Plan Preparationīefore doing the blocking, you should have planned your plot in detail, so you should have a good idea of premise, story beats, characters, locations and a summary outline of each proposed scene. This draft is a stepping stone between planning and drafting, and isn’t actually prose, hence it being called Draft Zero, rather than First Draft. The objective of Draft Zero is to put down a sturdy foundation for your First Draft to stand on. I’ve also added a very rough guide to projected timescales and a bullet point summary of each stage. what I do in advance) and then the technique I use when actually writing it. ![]() In the following sections I give details about the objective I assign to each draft, how I prepare for that draft (i.e. ![]() I try to approach each draft with different priorities in mind so I can focus on tackling particular elements of story-telling at each stage while setting aside other aspects for later so I don’t get bogged down trying to do too much at once. With drafting that means starting with a rough outline and slowly fleshing it out and adding detail, tweaking and weaving until it is finished, polished prose. The way I draft is an extension of the way I approach novel planning as a whole ( which you can read about here) – which is to start with a simple concept and then add more and more detail until I have a fairly comprehensive outline. These are the kinds of questions that I’ve pondered since I first started writing and developing my writing process, and this article is an attempt to summarize what I’ve learned so far in answer to these questions. How can you make the most efficient use of time?.What should you focus on during each draft?.I’m writing a first draft and reminding myself that I’m simply shovelling sand into a box so that later I can build sandcastles.In fact, two of my favorite writing quotes refer to just that: I’m not given to making dogmatic statements, but that’s one I’m willing to bet my manuscript on. Nobody writes their final novel on the first pass. ![]() Taking Part in NaNoWriMo this year? Check out our Ultimate Guide to NaNoWrimo for tips and tricks from writers and editors who have won NaNoWriMo before. ![]() ![]() ![]() You can use a professional language editing service of your choice if you want to. Such services include: Please check individual journal ‘About’ pages to confirm whether accepted manuscripts will undergo copyediting for style and language. Manuscripts submitted to most journals do not undergo copyediting for style and language. amsart (part of the standard TeX distribution).article (part of the standard TeX distribution).Springer article svjour3 (ZIP format) - preferred template.BioMedCentral_article (ZIP format) - preferred template.Failing to submit these source files will cause unnecessary delays in the production process. If an error is present then the system PDF will display LaTex code and highlight and explain the error in a section beginning with an exclamation mark (!).Īll relevant editable source files must be uploaded during the submission process. The Editorial Manager system checks for any errors in the Tex files. Please also note that all figures must be coded at the end of the TeX file and not inline. 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